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What is Mounjaro? And does it work better for weight loss than Ozempic and Wegovy?

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Wow! I don't have diabetes but gained weight while recovering from my PEs. I have lost 30 pounds but it came back because my body and my fat have becomes good friends and missed each other.😕


"Mounjaro is the newest diabetes drug that also triggers dramatic weight loss in people who inject it. The U.S. Food and Drug Administration (FDA) approved Mounjaro a year ago for patients with diabetes.

FDA officials have not approved Mounjaro for weight loss yet, but Low Wang said they are fast-tracking consideration of the drug. That’s because clinical trials have shown that people who do not have diabetes but do have elevated body mass indexes (BMI) used lost considerable weight when they used Mounjaro.

An FDA recommendation regarding Mounjaro for weight loss could come by the end of this year.

In the approval for Mounjaro for people with diabetes, federal health officials said it works well for people with Type 2 diabetes. That’s the most common form of diabetes, and more than 30 million Americans suffer from it.

Like Ozempic and Wegovy, it’s an injectable medication, but Mounjaro differs in some key ways from the other new, popular diabetes medications.

How does Mounjaro work? Why does it cause weight loss for people with diabetes?

“It suppresses appetite and makes you feel more full. It changes the rate at which your stomach empties,” Low Wang said.

Are Mounjaro, Ozempic and Wegovy the same drugs?

No. Ozempic and Wegovy are brand names for a drug called semaglutide. Mounjaro is the brand name for a different drug called tirzepatide. The drugs work in similar ways to reduce appetite, but there are some differences.

The drugs also are made by different companies. Eli Lilly makes Mounjaro, while Novo Nordisk makes Wegovy and Ozempic.

How does Mounjaro work?

“It’s a completely new drug class,” Low Wang said. “Instead of being a single-receptor agonist, which semaglutide (the drug in Ozempic and Wegovy) is, Mounjaro activates two receptors at the same time. That’s why it’s called a ‘dual-agonist.’”

This double agonist approach seems to cause people who use Mounjaro injections to lose even more weight than those who use a single-agonist medication.

These receptors stimulate hormones that control blood sugar levels and reduce appetite, triggering weight loss.

The receptors are known as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).

Wegovy and Ozempic activate the GLP-1 receptor, while Mounjaro activates two receptors: both GLP-1 and GIP.

How much weight do people lose with Mounjaro?

Low Wang said the weight loss data from the Mounjaro clinical trials have been stunning.

People who used the largest dose of Mounjaro, 15 milligrams, lost as much as 21% of their body weight.

“They were able to achieve unprecedented amounts of weight loss. It was dramatic and exciting,” said Low Wang, who receives no funding from pharmaceutical companies.

While losing significant weight, study participants also were able to keep their diabetes symptoms in check.

“We’ve never had a medication that is so effective for improving diabetes control and weight loss without putting patients at high risk of hypoglycemia,” Low Wang said.

Even so, time will tell how the drugs perform over time.

“The impacts on appetite and weight regulation are startling,” Low Wang said.

But people should not jump to conclusions and assume that Mounjaro will be a miracle drug.

“We still don’t know what the effects would be of taking Mounjaro for a short time, then going off of it. Does it change anything about your biology? Does it make it harder to lose weight in the future without a medication? We really don’t know yet,” Low Wang said."

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