Todd: we are not full timers so we travel, set up for a couple of weeks, move on and then back home. I think if we set up in one spot for more than three months a 5er would be a good option.
We came to this realization this January when Rick had to set up and get the Jeep off the tuck in the rain near San Diego. Our knees were killing us from the weather and our cats and dog had enough of being transferred back and forth from the truck to the 5er over the few days of travel enroute to our stop. When we came home we immediately looked for and found our new home on wheels. (Atypical of our purchasing process - it was a 6 month research/study process for the HDT/5er.)
We bought an Entegra Anthem and it is surprisingly not like a bus. If it had not been for this model I don't know we would be perfectly satisfied, but boy, do I LOVE it!! Climbing in and out is a lot easier for me even though Rick built SWS --- Short Wife Steps --- for the truck on the passenger side. (Which I highly recommend!! I felt so much safer climbing in and out.) We no longer have to transfer cats in and out with fear of dropping them; they stay in one home on overnight stops now. The dog doesn't have to jump from high heights to get out or climb vertical steps to get in. I always feared one of her nails would get caught and rip in the steps.
What I miss about the HDT are the air ride seats and bigger fuel tanks (MH means more stops at the fuel pumps). Rick says he misses the mirrors and the power for hills. I don't miss watching Rick reversing the Jeep off the back of the HDT. I don't miss having to guide the pin of the trailer onto the hitch in the heat, cold or rain.... honestly, it's easy enough to do, it's just now I don't have to do it and I like that!!
Like Phil said about the driver cockpit of an MH, we also didn't like the idea fearing we wouldn't have separation from driving and relaxing. Honestly, there has been no problem. We turn the captain chairs around to face the living room and they become our cat chairs. The one thing I miss in the 5er is the height of the ceilings. I love tall ceilings even though I'm short, lol. Other than that, I sure don't miss the steps leading to the bathroom, or the small stool closet. Of course, depending on the MH there may still be that issue.
I was comfortable driving the HDT (three pedal auto-shift), but I prefer driving the MH more. Rick says it's because the steering wheel is tighter. And I do miss waving at HDT drivers and being the center of the attention at a campground. Just kidding on that last one, but I really did like giving a two-finger wave and talking to drivers who liked our set up.
In the end, I am really glad we went the route of the HDT and 5er - it was the best option for us at the time. We both enjoyed that lifestyle and because of it I've made lifelong friends via the Rallies. Heck, even Jack likes me!!